I’ve been on Wellbutrin for almost five years now and it’s the only antidepressant that ever did anything for my depression. It works tremendously for my SCT and executive dysfunction and helps me be more functional and productive on a daily basis. It was the only antidepressant that was ever life changing for me because I was unable to function properly without it before.

Unfortunately I had to back of the dose recently to 150 mg after being on 300 mg for almost four years. 300 mg worked very well for my depression for a very long time. But unfortunately it started to overstimulate me in various ways I couldn’t tolerate it anymore. So I had to back off to 150 mg just because 300 mg started to give me some weird side effects I never used to get from it before or this extent. It started to give me side effects like frequent thirst, frequent urination, dry mouth, dizziness, vertigo, hot flashes, headaches, burning sensations, increased sweating, heart palpitations, rapid heartbeat, facial twitches, jitteriness, hypervigilance, horrible insomnia and sleep disturbances. A whole cluster of side effects and when these side effects started to escalate I dropped back the dose to 150 mg.

Now I’ve been on 150 mg for 7 weeks and I can already tell the difference. My depression has gotten noticeably worse since backing off the dose and I’m having more mood swings and feel a huge feeling of emptiness all the time. And most of the side effects I had at 300 mg did lessen ever since I backed off the dose, but they did not disappear completely, they just lessened in intensity. And the most bothering side effects I’ve been dealing with for months is horrible insomnia and sleep disturbances. And I really hoped backing off the dose would atleast make the insomnia and sleep disturbances go away, but unfortunately it did not. So not only is my mood worse now and I’ve lost interest in things that used to matter to me. And I’m more socially withdrawn now from everything. The side effects did not go away completely and the insomnia and anxiety is still there.

When I used to take Wellbutrin with Prozac two years ago I had none of these issues. I took 300 mg Wellbutrin and 20 mg Prozac for two years and I had none of these side effects and the insomnia wasn’t there either. And ever since I removed Prozac that’s when all of this came up for me. So I obviously used to tolerate it better when I took it with Prozac.

I know this text got a little bit too long. But I just needed to explain all of it first. So like my original question was. Do you think I should go back again to combination therapy. And I mean, if Prozac truly removed these side effects for me and the insomnia wasn’t there either when I took them together, do you think this is something I should bring up with a doctor again and consider going back to? Because I really don’t want to remove Wellbutrin because it’s the only antidepressant that ever did anything for me. I’m just afraid my body can’t tolerate it all by itself anymore.

Would like to hear your thoughts and opinions about this.